Purpose of the study. To enhance the efficiency of combination treatment using topical immunotherapy in patients with chronic salpingoophoritis.

Material and research methods. Seventy-five patients aged 25 to 36 years, who had been admitted to a gynecology department with a diagnosis of tuboperitoneal infertility caused by chronic salpingoophoritis for elective diagnostic and therapeutic laparoscopy, were examined. After the women gave a preliminary voluntary written consent, their blood was taken to determine the serum concentrations of the neutrophil antimicrobial peptides HNP1-3. According to the performed treatment, all the examined patients were divided into 2 groups:

1) 37 patients in whom, in addition to surgery and antibiotic therapy, the immunotropic drug Superlymph was incorporated into combination treatment for infertility;

2) 38 patients who received standard treatment, control group comprised 15 women without a history of gynecological diseases who had been admitted to hospital for painful ovarian apoplexy.

Research results and their discussion. The investigation has shown that the incorporation of the immunotropic drug Superlymph promotes hyperproduction of the antimicrobial peptide HNP1-3 that plays a key role in the activation of innate immunity and in the antimicrobial protection of the genital tract mucosa in the combination treatment of patients with chronic salpingoophoritis. This results in a reduction in relapse rates of an inflammatory process in the uterine appendages and an improvement of reproductive function.

Conclusion. The developed procedure and assessment of long-term treatment results may lead to the conclusion that surgical correction of infertility in combination with topical immunotherapy is effective in patients with tub peritoneal infertility caused by chronic salpingoophoritis.

Aim. Conduct clinical and hygienic condition of nearteeth tissues beside patients with anatomist-functional disorders of mucous-gingival complex thresholds of oral cavity.

Material and methods. The clinical and epidemiological study of dentistry status was organized for achievement of the delivered problems, in which have took part 498 patients with caries and parodontal pathology. From the common amount of examined patient beside 167 (33.5%) of them diagnosed anatomist-functional disorders of mucous-gingival complex , which were divided into 3 groups. In first clinical group 64 (38.3%) patient were enclosed with average threshold of oral cavity, II type of the correlation division free and attached games, average and get fat biotype of the gums, II type of the correlation division free and attached games, II type of the fastening bridle lips, without clinical symptoms needs thresholds, bridles or lateral bridle of mucous oral cavity in correction.

In second group entered 57 (34.1%) patient with small threshold of the oral cavity, which had a correlation division free and attached games on II type, fine and average biotype of the gums, and II type of the fastening bridle lips or mucous shell of oral cavity, as well as their hypertrophy, with positive symptom’s needs enumerated anatomical structures in correction. In third group entered 46 (27.6%) patient with afore-mentioned anatomist-functional disorders, discovered in second group, as well as are discovered recession games III, but coronal comparatively apical to border of vestibule recession.

Results. Amongst examined patient with average threshold of the oral cavity factors of the index hygiene on Fedorov-Volodkin beside 25 (34.3%) patients corresponded to good level, beside 29 (39.7%) patients they corresponded to satisfactory level, beside 13 (17.8%) patients level hygiene was estimated as unsatisfactory, but beside 6 (8.2%) patient as bad.

Conclusion. Factors of the hygienic condition of oral cavity beside patient with anatomist-functional disorders of mucous-gingival complex in greater degree were indicative of insufficient satisfactory level, that can be the full-fledged moving conditioned by impossibility of the performing the toothbrush when cleaning teeth.

Purpose of the study. Development and implementation of recommendations for improving medical and social assistance to persons of retirement age based on a comprehensive social-hygienic and medical-demographic study of the health status, lifestyle and state of gerontological care for the elderly population in the republic.

Material and methods of the research. An analytical review of aging in the Republic of Tajikistan, national legislation and international recommendations on issues of older people was conducted. The qualitative methods studied were: focus group discussions, individual interviews, in-depth interviews, interviews with experts, psychological testing. The research materials were the reporting and accounting documentation of medical and preventive and medical and social institutions, as well as questionnaires developed for elderly people on medical and social issues.

Results of the study and their discussion. As a result of the study, it was found that only 8% of those surveyed had no education, and they were women, 34% had higher education, 28% had secondary education, and 30% had vocational education. The survey found that all beneficiaries’ main income was only their pension, even if they had higher education and professions that are currently in demand (teacher, doctor). It was found that 56% of beneficiaries had a great desire to work, however, they were not hired because of their age. This attitude towards the elderly is a violation of human rights through discrimination against them based on age, although it is well known that the elderly are a huge human capital and can make a significant contribution to the economic development of the country. The same attitude of employers was revealed towards disabled people of groups 2 and 3, which is a manifestation of the infringement of rights and dignity. The problem for everyone is the small pension size, which does not satisfy their needs, despite the level of education. They experienced difficulties in acquiring the necessary medications. In self-assessment of health, all assessed their health as “average”. None of the beneficiaries were prepared for old age either psychologically, physically or financially, beneficiaries especially point to loneliness, lack of attention, which indicates ignorance of issues of the culture of aging.

Conclusion. The conducted analysis showed that the structure of health care for full coverage of persons over 60 years of age, provision of medical care requires training a sufficient number of gerontologists and development of gerontological service in the republic. Low pensions dictate the need to provide access to work for elderly people, which will improve their economic situation. It is necessary to conduct information work to prepare the elderly for active and healthy aging.

Aim. To analyze the incidence and mortality from breast cancer for the period 2016-2023 in the Republic of Tajikistan.

Materials and methods. The data of the form No. 7 submitted by the Center for Medical Statistics and Information of the Ministry of Health and Social Protection of the Population of the Republic of Tajikistan for 2016-2023 and the reporting data to the departments of Mammology and Reconstructive Surgery of the State Scientific Research Center of the Ministry of Health and Social Development of the Republic of Tajikistan have been studied. The data on morbidity and mortality, the degree of prevalence by age and stages were studied.

Results. In the Republic of Tajikistan, the incidence of breast cancer is also increasing annually, especially over the past two years (compared to 2016-2021, 1.5-1.7 times more breast cancer patients were identified in 2022-2023). Mortality from breast cancer in the republic decreased by 0.8-0.9 times in 2022-2023 compared to previous years. 63-75.3% of cases are detected in stage I-II, 10.3–20.9% in stage III, and 10.3-17.6% in stage IV. There is a tendency towards the “rejuvenation” of breast cancer in the Republic of Tajikistan.

Conclusion. The incidence and mortality from breast cancer in the Republic of Tajikistan, as in other countries of the world, is growing dynamically every year. Despite the high incidence rates, mortality is decreasing from year to year. As in all countries of the world, there is a tendency towards the “rejuvenation” of breast cancer in our republic.

Purpose of the study. To determine the effectiveness of modern methods of treating MGD in women with pathology of the pelvic organs.

Material and research methods. The study material included 290 patients with benign neoplasms of the mammary glands who sought medical help at the gynecological department of the Institute of Obstetrics, Gynecology and Perinatology of Dushanbe in the period from 2015 to 2022. The first group consisted of 127 (main group) patients with dishormonal diseases of the mammary glands in combination with pelvic inflammatory disease, the second group consisted of 163 (comparison group) patients with dishormonal diseases of the mammary glands in combination with benign ovarian tumors.

Research results and discussion. Therapy in the groups was based on the factors on which MGD developed: in the first group, patients were examined for STIs and bacterial cultures were taken. Therapy included antibacterial therapy, taking into account the identified infectious agent and sanitation of lesions. In group II, treatment consisted of removal of true ovarian tumors, the restoration of the cycle for which they received the COC Lindinet -20 for 3-6 months. The results of the study showed that in the process of complex therapy, positive dynamics in the condition of the mammary glands was observed in patients of both study groups. By the end of the first year of observation, improvement was noted in the prevailing majority of patients in both groups: 96/75.5±3.8% and 134/82.2±3.0%, respectively, in groups I and II.

Conclusion. Considering the large-scale and diverse background of the occurrence of mastopathy, it is necessary to note the absence of a unified scheme for pathogenetic therapy of MGD. Therefore, treatment should be aimed at the factors, causes, or combination thereof that led to the development of mammary gland pathology.

Purpose of the study. To determine the efficacy of dienogest (Vizanne) at a dose of 2 mg in the treatment of premenopausal patients with adenomyosis.

Material and research methods. We examined 21 women in the gynecology department of the Research Institute of Obstetrics, gynecology and Perinatology, aged from 39 to 49 years, suffering from adenomyosis, complicated by menstrual dysfunction and pelvic pain syndrome. The inclusion criteria for the study were the absence of indications for surgical treatment, diffuse and local adenomyosis .

Results of the study and their discussion. The effectiveness of treatment with dienogest (Vizanne) at a dose of 2 mg for 6 months in relation to the therapy of endometriosis in women of these age groups has been proven clinically, which was characterized by the absence of pain syndrome and acyclic menstrual bleeding. Ultrasound examination of the pelvic organs showed a decrease in the severity of adenomyosis. After 6 months of treatment, all patients showed stable remission of the disease and amenorrhea.

Conclusion. Conducted studies indicate that the use of the antiproliferative drug Visanne can reduse hysterotopic endometrial inclusions in the myometrium, improve the state of myometrial architecture and thereby alleviate the clinical manifestations of the disease, accompanied by debilitating pelvic pain.

The purpose of the study. Study of the activities of the President of the Republic of Tajikistan to achieve peace and unity.

Materials and methods of the study. In the process of researching the topic, scientific materials, historical sources, numerous decrees of the Government of the Republic of Tajikistan were used.

Results of the study and their discussion. The study pays special attention to the materials of the 18th session of the Supreme Council of the Tajik Republic, materials. Agreement on universal peace and national accord.

Conclusion. In conclusion, the analysis and results of identical cases in the history of other countries and the application of historical experience to achieve peace and national accord in our country were carried out. About the merits of the Leader of the Nation, President of the Republic of Tajikistan E. Rahmon in establishing peace and strengthening state independence.

Research objective: To determine the effects of climate change and glacier melting on the territory of Tajikistan.

Research materials and methods. On the need to protect glaciers from various literature used in various domestic and international conferences on climate change.

The results of the research and their discussion. It is necessary for all people of the world to contribute to global warming of the planet, not to remain neutral.

The results of the research were discussed at the meetings of the department and republican conferences

Conclusion: The transition to digital media and access to high-resolution satellite imagery has expanded the possibilities for glacier research.

Aim. Clarifying the current situation of the child’s situation in the family, resolving misunderstandings between the child and parents.

Materials and methods of research. The research is based on statistical databases, including statistical reports, analysis of scientific-theoretical and informative materials in the field of family and community psychology.

The results of the study and their discussion. The results of the research are devoted to the child’s mental state in various situations, and the ways to get rid of the child from an aggressive state are elaborated. The causes of aggression in children and adolescents are also discussed.

Conclusion. One of the ways to save a child from aggression is the equal distribution of the child’s inner strength by the parents, as a result of which the child is constantly engaged in an activity.

There is an increase in burn injuries in people of working age, most often in men, resulting from accidents at work, at home, during recreation, or associated with criminal offenses.

The effectiveness of treatment depends on the type of damaging agent, timely provision of emergency care and the time of admission to the hospital.