Features of the hormonal function of the placenta and morphological characteristics of the placenta in obese pregnant women
Abstract
The purpose of the study. Study of the characteristics of the hormonal function of the placenta and morphological evaluation of the placenta in women with obesity.
Research materials and methods. A total of 136 patients including 109 pregnant women with obesity (main group) were prospectively observed. This group, in turn, is divided into three groups: obesity in the patient 40 patients, obesity + preeclampsia 39 patients and obesity + insulin resistance 30 patients. The control group consisted of healthy pregnant women. Histological analysis of placentas of women who gave birth (p=24) was performed.
Research results and discussion. The conducted analyzes showed a decrease in the intermediate level of mashima hormones estradiol, PLH, progesterone, which contributes to timely fertilization of the baby’s uterus.
Summary: 1. Hormonal data showed a decrease in the level of hormones in pregnant women with obesity (estradiol, HLP and progesterone), the statistical significance of the decrease in the level of progesterone was found in pregnant women with obesity and SSDBT. 2. Histological assessment of placentas showed that 78.6% of pregnant women with obesity and preeclampsia have chronic placental insufficiency, which is manifested as hypoplastic type (55.5%) and dissociation (45.5%) with the type of placental development. which has a negative effect on the prenatal development of the fetus and perinatal consequences.
References
1. Borovkova E.I., Makarov I.O., Bayramova M.A. Perinatal outcomes in patients with obesity and unfavorable biochemical screening // Bulletin of the Peoples’ Friendship University of Russia. -M.-2011. -No.6,-P.116-121
2. The influence of endothelium-mediated factors on the formation of obstetric pathology in metabolic disorders [Electronic resource] /
3. V.E. Radzinsky, N.V. Palieva, T.L. Botasheva [and others] // Modern problems of science and education. 2016. No. 5. URL: http://www.science-education.ru/ru/article/view?id=25145. Cap. from the screen. (date of access: 09/27/2016).
4. Dubova E.A., Pavlov K.A., Borovkova E.I. et al. Vascular endothelial growth factor and its receptors in the placenta of obese pregnant women // Bulletin of Experimental Biology and Medicine. -M.-2011. -No. 2. -P.218-223
5. Seregina, D.S. Obesity is the leading pathogenetic link in the pathological course of pregnancy and childbirth [Text] / D.S. Seregina, I.P. Nikolaenkov, T.U. Kuzminykh // Journal of obstetrics and women’s diseases. -2020.-№2.T. 69.-P.73-82.
6. Kamilova, M.Ya. Changes in placental hormones and apoptosis markers in women with threatened miscarriage and complicated miscarriage [Text] / M.Ya Komilova, D.M. Rakhmatulloeva, S.U. Arabova // Sciences of Europe No. 14. 2017. -S. 45-48.
Review
For citations:
Oripova R.Sh. Features of the hormonal function of the placenta and morphological characteristics of the placenta in obese pregnant women. Herald of the medical and social institute of Tajikistan. 2023;(3):38-42. (In Russ.)
Views:
40
Email this article 