Laboratory and clinical characteristics of pregnant women with obesity

Abstract

Purpose of the study. To study the laboratory and clinical characteristics of pregnant women with obesity.

Material and research methods. A total of 139 patients were examined, including 109 pregnant women with obesity (main group). This group, in turn, is divided into three subgroups: obese - 40 patients, obesity + preeclampsia - 39 patients and obesity + insulin resistance - 30 patients. The control group was formed from among healthy pregnant women - 30 patients. The results of the obtained data were processed by the method of variational and descriptive statistics using the Student’s criteria, the Mann-Whitney U-rank test. Qualitative comparisons of populations were performed using chi-square analysis, corrected if necessary by Yates.

Research results. The results of our study showed that the predominant majority of pregnant women with obesity were in active reproductive age - 73.6% and in late reproductive age - 26.4% of women, respectively (Figure 1). At the same time, out of the total number of women in adolescence (18-19 years), there were two (1.8%) obese pregnant women.

Conclusion. The results of our study showed that in pregnant women with obesity, there is a gradual deterioration in lipid and carbohydrate metabolism parameters with the progression of pregnancy, which adversely affect perinatal outcomes. The Homa index can be used as a marker of insulin resistance indicating a change in carbohydrate metabolism in obese women.