Information value of the results of clinical and laboratory studies in prediction of outcomes of NV - viral infections in children

Abstract

Aim. To assess the informational value of clinical signs and results of laboratory and instrumental studies for predicting the development of unfavorable outcomes in HBV infection in children, aimed at taking measures aimed at early diagnosis, and prescribing adequate therapy.

Materials and methods. The study included 167 children with acute viral hepatitis B (AVHV) and 113 children with chronic hepatitis B (CHB) both during the period of an active pathological process and during the period of convalescence. The diagnosis was established on the basis of clinical and epidemiological data and biochemical results (determination of the level of bilirubin and its fractions, the activity of hepatocellular enzymes, protein-sediment samples, total protein and protein fractions, the main classes of immunoglobulins, circulating immune complexes) serological HBV (HBsAg anti-HBs, HBeAg anti-HBe, anti HBc IgM), morphological and instrumental (ultrasound) studies.

Results and discussion. The preicteric period in AVHV was most often accompanied by asthenicvegetative syndrome (79.5%), the symptoms of intoxication, the severity of which corresponded to the severity of the disease. In 10.3% of patients, there were no signs of the preicteric period. This stage of AVHV lasted 5-7 days in most patients (8.7%), in the rest - up to 2 weeks. It should be emphasized that the onset of the disease was short in severe forms of the pathological process, which is consistent with the data of other authors [4].

Conclusion. Summarizing the data on the chronic course of HB viral infection, it can be stated that liver damage of minimal activity in most cases ends in persistent remission, often with the complete disappearance of all clinical and laboratory diseases; CHB with a pronounced activity of the pathological process proceeds for a long time with rare and short-term remissions.