The role of tumor markers in the diagnosis of women with benign ovarian tumors

Abstract

Purpose of the study: to study the role of tumor markers in the examination of women with ovarian tumors and to determine the most important criteria for prognostic diagnosis.

Materials and methods of research: The study included women who were under observation in the consultative and diagnostic clinic of the State Research Institute of Aging, as well as those hospitalized in the gynecological department of the institute. Of these: мain group 177 (54,1%) women with benign ovarian tumors, comparison group – 107 (32,7%) women with ovarian tumors, control group – 43 (13,2%) healthy women.

Results and their discussions: Having analyzed the results of 80 blood serum samples from patients with pre-occlusive tumors and 54 from patients with general neoplasms for the tumor marker CA-19.9, it was found that the concentration of this antigen was within the reference values: 23.9±1.37 IU/ ml and 19.2±1.17 IU/ml, respectively. The obtained data had statistically significant differences (p<0.01) from similar indicators for women in the control group. An increase in the concentration of CA-125 above the reference values (35 IU/ml) occurred in 4 (17.4 ± 7.1) of 23 patients with endometrioid cysts and in 3 (13.0 ± 7.0) of 23 patients with dermoid cysts ovaries. Additional studies of tumor markers CEA and CA-19.9 showed the concentrations of these tumor markers within normal values. When calculating MI in patients of the main group, this indicator was less than 200, averaging 24.7±2.9.

Conclusion: Thus, determining the level of tumor markers and calculating the malignancy index in patients with adnexal formations in the preoperative period make it possible to determine the profile of the hospital where surgical treatment is necessary and to monitor the effectiveness of the treatment. At high levels of CA-125 additionally, the concentration of CA-19.9 and CEA should be determined in order to clarify the possibility of malignancy of formations