EFFECTIVENESS OF NITRIC OXIDE DONOR – TIVORTIN AND ITS ROLE IN HEART REMODELING OF PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE IN COMBINATION WITH ARTERIAL HYPERTENSION COMPLICATED BY CHRONIC HEART FAILURE

Abstract

The purpose of the study. Studying efference of Tivortin and its role in cardiac remodeling in patients with chronic ischemic heart disease in combination with arterial hypertension, complicated by chronic heart failure.

Materials and research methods. 75 patients (30 men and 45 women) with exertional angina pectoris of the III functional class, hypertension of the II degree and chronic heart failure of the I-II functional class, who were treated at the Clinical Scientific and Educational Center(CSEC) at the PEI “Medical and Social Institute of Tajikistan” from 50 to 75 years, were examined. The patients were conditionally divided into two groups. The first group included 53 (73,3%) patients with the above pathology who received Tivortin solution 4,2%-100 ml/d, the second group included 29 (28,7%) patients, who did not receive Tivortin.

Research and observation results. Intravenous use of Tivortin solution 4,2% in complex treatment against the background of basic therapy in patients with chronic ischemic heart disease in combination with arterial hypertension, complicated by chronic heart failure, led to an improvement in the clinical condition of patients and hemodynamic parameters.

Conclusions. Tivortin is an effective treatment for angina pectoris of the III FC, hypertension of the II degree and chronic heart failure of the I and II FC. Improves functional class, normalizes diastolic replenishment of the left ventricle and reduces the incidence of complications and development of myocardial infarction (IM).